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1. Definition
Antinuclear antibody is defined as specific class of auto antibodies that have the ability to attack structures in the nucleus of cells instead of performing the normal antibody function. It can be detected through blood sample withdrawn from the patient vein.
2. Causes
a) Infection and inflammation
Infection and inflammation caused by bacteria or virus speeding up the body immune system function, but in some cases, bacteria and virus induce the immune system to produce antibodies which directed against the tissues of the body including antinuclear antibody.
b) Medication
i) Phenytoin
Pheytoin may increase the risk of production of antinuclear antibody, leading to increasing the risk of malformations and birth defects.
ii) Antibotics
Long term uses of antibody may increase the rick of the production of antinuclear antibody as the medication causes abnormal reaction to the immune system.
iii) Methyldopa
The medication is used to dilate blood vessels for treating high blood pressure, but long term use of this type of medication may decrease the risk of immune disorder in production of antinuclear antibody.
c) Aging
As we age, the levels of antinuclear antibody increases and in some older adults (5% to 40%) may have mildly elevated levels caused by weakening immune function.
d) Diseases
Some diseases such as lupus erythematosus and rheumatoid arthritis may also increase the rick of the production of antinuclear antibody.
3. How antinuclear antibody effects infertility
Under normal conditions, when a woman becomes pregnant, the white blood cells in her uterus produce protective, blocking antibodies. In case of antinuclear antibody, the white blood cells recognize the fetus as a foreign invasion and attack it, leading to miscarriage.
4. Treatment
a) Heparin
Heparin is a member of anticoagulants,it is a purified preparation derived from animal tissue. It helps to increase the blood in transportation of nutrients to the reproductive organs leading to high chance of fertility and lessening the risk of pregnancy loss.
b) Aspirin
Aspirin is an anti-inflammatory and blood thinner agent, it helps to increase the blood circulating to the reproductive organs, thereby reducing the risk of antinuclear antibody attacking the fetus or the women reproductive tissues. It is recommendation to take 80 mg per day, which is equivalent to a baby aspirin. if necessary.
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